bioF [2017-05-23 15:07:24]

8-amino-7-oxononanoate synthase

locus: BSU30220

pI: 6.28

mw: 42.42 kDa

protein length: 389 aa

gene length: 1167 bp

function: biosynthesis of biotin

product: 8-amino-7-oxononanoate synthase

essential: no

ec: 2.3.1.47

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin]

Gene

Coordinates: 3,092,184 → 3,093,353

The protein

Catalyzed reaction/ biological activity

• 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO₂ (according to Swiss-Prot)

Protein family

• class-II pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)

Structure

• [PDB|3A2B] (Serine palmitoyltransferase from Sphingobacterium multivorum, 37% identity) [pubmed|19564159]

Expression and Regulation

Operons

• genes: [gene|C40116089BAD3F9831F8C837DC4F2E045753ABDE|bioW]-[gene|68C86FED3575B864C576DFB73FE7B5BF83994D1F|bioA]-[gene|8B6A3E86A88928526D94FDA94B9C81ABF6E9ACFB|bioF]-[gene|D9A71DAF949FB6C9C22C8361D83C5A0741184977|bioD]-[gene|5880617EB95FC0D19219A868D6D0A3D1D0D9C532|bioB]-[gene|8FBC9A1AC108DC99E275D7A27C18C797D3CDB936|bioI]-[gene|089A32D08B5A7E552CBD9CB9745BD542863B4558|ytbQ]
  description: [Pubmed|8763940,8892842]

  regulatory mechanism

  • [protein|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|BirA]: repression, [Pubmed|8763940,8892842], in [regulon|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|BirA regulon]

  regulation

  • repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]

Reviews

• 21437340

Original publications

• 8763940,8892842,21821766,22960854,19564159